Optimizing Continuous-flow Left Ventricular Assist Device Settings and Identification of Pump Malfunction - A Comparative Study of Echocardiography and Invasive Hemodynamics

Rigshospitalet, Denmark15 enrolled

Overview

The purpose of the trial is to identify factors which can be used as guidance when optimizing continuous-flow left ventricular assist device (CF-LVAD) settings. The hypothesis of the study is that pulmonary capillary wedge pressure (PCWP) will change independently of left ventricular end diastolic diameter (LVEDD) when increasing pump speed ie ΔPCWP/RPM ≠ ΔLVEDD/RPM. The primary combined endpoint of the study is correlation between ΔPCWP and LVEDD slope under ramp testing in a cohort of "continuous-flow left ventricular assist device" heart failure patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heart Failure.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Heart failure patients with HeartMate II (HM II) followed as outpatients at The Heart Centre at University Hospital of Copenhagen, Rigshospitalet. * Age \> 18 years. * Heart failure in stable phase without the need for intravenous inotropic therapy. * Ischemic or non-ischemic cardiomyopathy. * Signed informed consent. Exclusion Criteria: * Unstable patients with the need for intravenous inotropic therapy. * Current hospitalization. * Implantation of HM II less than one month ago.

Locations (1)

University Hospital Rigshospitalet.

Copenhagen, Kbh Oe, Denmark

Optimizing Continuous-flow Left Ventricular Assist Device Settings and Identification of Pump Malfunction - A Comparative Study of Echocardiography and Invasive Hemodynamics

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes