Comparative Bioavailability of Two Forms of Vitamin C

Inclusion Criteria: * Healthy as determined by laboratory results and medical history * Females not of child bearing potential * BMI 18-30 kg/m2 * Agrees to consume a low vitamin C diet * Non-smoker or ex-smoker \>1 year Exclusion Criteria: * Pregnant, breastfeeding, or planning to become pregnant during the trial * Alcohol \>2 drinks per day; alcohol or drug abuse within the past year * Cardiac conditions * Duodenal ulcer or gastric ulcer, gastritis, hiatus hernia, or gastroesophageal reflux disease (GERD) within past 3 months * History irritable bowel syndrome, malabsorption or significant GI disease * History of kidney stones * Use of medications known to interact with vitamin C * Use of supplements containing vitamin C * Use of anticoagulants (warfarin), barbiturates, tetracycline antibiotics, beta-blockers, cyclosporine, prednisone, tricyclic antidepressants, diuretics and nitrate medications * History of or current diagnosis of cancer * Uncontrolled hypertension * History of diabetes, renal disease and/or liver disease * Unstable psychiatric disorder * History of or current immunocompromise * History of hemochromatosis or hemoglobinopathies * Participation in a clinical research trial \<30 days * Use of acute medication w/in 72 hours of intervention * Unstable medications \<90 days * Abnormal liver function * Serum creatinine \> 1.5 x upper limit of normal (ULN) * Anemia of any etiology * Blood donation w/in the last 2 months * Allergy or sensitivity to test articles, foods or beverages provided during the study * Cognitive impairment and/or unable to give informed consent