Bioequivalence Trial of Alprazolam 0.25 mg Tablets

Inclusion Criteria: * Free will participation according to Mexican regulation, Helsinki Declaration, and Good Clinical Practice. * Healthy, between 18 and 50 years. * Body Mass Index between 18 and 27.5 * In good health by complete medical history and laboratory tests. * Blood pressure 130-90/ 90-60 mm Hg; heart rate 55-100 beat per minute, respiratory rate 14-20 movements per minute. * Laboratory tests +/- 10% of normal interval (blood cytology, blood chemistry 27 elements, Hepatitis B and C antigens, HIV, urinalysis, anti-doping, pregnancy, electrocardiogram Exclusion Criteria: * Alteration of vital signs * Not complying with inclusion criteria * History of cardiovascular, kidney, hepatic, muscular, metabolic, gastrointestinal (including constipation), neurologic, endocrine, hematopoietic (any kind of anemia), asthma, mental or organic disease. Those suffering from muscular trauma 21 days before the beginning of the study. * Requirement of any kind of medication during the course of the study, except study medication. * History of dyspepsia, gastritis, esophagitis, duodenal or gastric ulcer. * Exposure to medications known as inducers or inhibitors of hepatic enzymes or administration of potentially toxic medication in the 30 days before the study beginning. * Administration of any medication in the 14 days or 5 half-lives (whatever longer) previous to the beginning of the study. * Hospitalization for any cause in the seven months before the beginning of the study. * Administration of investigational drugs in the 60 days before the study. * Allergy to any medication, food, or substance. * Alcohol ingestion or intake of beverages containing xanthines (coffee, tea, cocoa, chocolate, mate, cola drinks) or ingestion of charcoal grilled food or grapefruit or orange juice in the 72 hours before the hospitalization or tobacco smoking in the 72 hours before the beginning of the study. * Blood donation or loss =\> 450 ml in the 60 days before the beginning of the study. * History of drug or alcohol abuse. * Special diet requirement, for instance vegetarian diet. * Inability to understand nature, aims, and possible consequences of the study. * Non-cooperative attitude during the study. * Positive anti-doping or pregnancy test. * Breast-feeding. * Females on hormonal treatment.