3 Airway Clearance Techniques in Non Cystic Fibrosis Bronchiectasis

Hospital Clinic of Barcelona31 enrolled

Overview

Study design: a randomized, crossover trial. Each patient performed three different airway clearance techniques (Autogenic drainage, slow expiratory with glottis opened in lateral posture \[ELTGOL\], temporary- positive expiratory pressure \[T-PEP\] with not similar autonomy degree in a randomized order. Each technique were applied in 3 sessions during one week at alternate days (Monday /Wednesday/Friday or Tuesday/Thursday/Saturday). The time spent in each bronchial session was 40 minutes. Seven days were the wash-out time period between the different techniques.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Bronchiectasis

Interventions

Autogenic drainageOTHER

It was performed following J. Chevallier recommendations.In this trial it was considered a self-administrated technique because physiotherapist only gave oral advice in order to ensure a correct performance of the technique.

Slow expiration with glottis opened in lateral postureOTHER

It was performed following Postiaux´s recommendations. In this trial the technique was considered active-assisted because the physiotherapy played a role important in their execution.

Temporary-positive expiratory pressureOTHER

The diaphragmatic breathing was required for this technique whereas patients remain seated in front of the device with a nose clip. The inspiratory /expiratory ratio was 1:2.It was taken into account as a device-administrated technique for this trial.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. \- Non Cystic Fibrosis bronchiectasis diagnosed by High Resolution Computed Tomographic 2. \- Mean sputum production ≥ 15 ml /24h 3. \- Clinical stability in the last 6 weeks 4. \- Not carrying out regular chest physiotherapy 5. \- Forced expiratory volume in 1 second ≥ 30% pred. ; Forced Vital Capacity ≥ 45% pred. and peak expiratory flow \>270 L/s Exclusion Criteria: 1. \- Smoker or non-smoker form less than 2 years 2. \- Cystic fibrosis 3. \- Active tuberculosis or sarcoidosis

Locations (1)

Hospital CLinic

Barcelona, Barcelona, Spain

Outcomes

Primary Outcomes

Weight of sputum expectorated during each airway clearance therapy session

Wet weight sputum production were recollected in one pre-weighted containers. It was measured in grams.

Time frame: 40 minutes

Weight of sputum expectorated 24 hours post each bronchial session

Wet weight sputum production were recollected in one pre-weighted containers. It was measured in grams.

Time frame: 24 hours

Secondary Outcomes

Saint George Respiratory Questionnaire (SGRQ)

Saint George Respiratory Questionnaire (SGRQ) is a self-completed health-related quality of life questionnaire.It was validated in bronchiectasis. It was administrated at the start and at the end of trial.

Time frame: Change from baseline at 5 weeks

Leicester Cough Questionnaire (LCQ)

Leicester Cough Questionnaire is a self-completed quality of life measure of the impact of cough severity. It was validated in bronchiectasis. It was administrated at the start and at the end of each technique.

Time frame: Changes from baseline arm to 1 week

Data from ClinicalTrials.gov

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