A Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of N-Rephasin® SAL200 in Healthy Male Volunteers

Inclusion Criteria: * Healthy male subject whose age is 20 \~ 45 at the time of screening visit. * Body weight of ≥50kg and \<90kg, while within ±20% of the ideal body weight. \[ideal body weight(kg) = {height(cm)-100}x 0.9\] * Subject agreed to participate in the trial and to follow all of trial-related rules with a full understanding, after having a full account of the trial Exclusion Criteria: * Present disease(s) or medical history(ies) which is(are) clinically significant on liver, heart, nervous system, respiratory system, haemato-oncology, cardiovascular or psychopathy. * Diagnosed or suspected infectious disease within 30 days in prior to the administration. * Clinically significantly allergic to drug(s) containing AI of N-Rephasin® SAL200 or to other drugs including aspirin and antibiotics, or has medical history(ies) on such allergy. * Already has taken other drug(s) containing AI of N-Rephasin® SAL200. * Positive for Antibody of N-Rephasin® SAL200. * SBP≤90mmHg or DBP≤50mmHg, otherwise, SBP≥150mmHg or DBP≥100mmHg in Vital sign which was measured after taking 3 minutes of resting in sitting position. * Has medical history of drug abuse or positive to drug abuse in urine drug screening. * Has taken any prescription drug(s) or herbal medicine(s) within 14 days prior to the administration, otherwise, any OTC(Over the counter) (s) or vitamin(s) within 7 days prior to the administration(However, can participate in the study if investigator makes a decision that the subject can participate regardless the drug taken). * Has taken any other study drugs within 2 months prior to the administration. * Has donated blood(whole blood donation or component transfusion) within (2 months or 1 month, respectively) in prior to the administration, otherwise, has received blood transfusion within 1 month in prior to the administration. * Smoke at present or positive to metabolism of nicotine in urine test. * Drink regularly(over 21 units/week, 1 unit= 10 g of pure alcohol), otherwise, is not able to interrupt drinking and smoking in study period. * Investigator made a decision that the subject is not eligible based on results of laboratory test or other reason. * Not agree with contraception for 60days after the administration, otherwise, notification of pregnancy in case of his partner is pregnant for 90 days after the administration.