Purpose: To compare efficacy and safety of traditional sliding scale insulin (SSI) versus modified 70/30 insulin versus modified basal plus supplemental scale /bolus insulin regimens for glycemic control in hospitalized diabetic patients with diabetes. Methods: In a prospective trial, patients with diabetes will be randomized to receive either traditional hospital SSI , or twice daily 70/30 insulin plus supplemental lunchtime insulin for BG ≥ 150 mg/dL or once every night glargine plus three times prandial glulisine for BG ≥ 150 mg/dL . 70/30 insulin and glargine will be started respectively at 0.4 and 0.2 U/kg/day for BG ≤ 200 mg/dL or 0.5 and 0.3 U/kg/day for BG above 200 mg/dL.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
63
the department of internal medicine, Cairo University teaching hospitals,
Cairo, Egypt
Mean Daily Blood Glucose (BG) Concentration During Their Hospital Stay.
Time frame: during hospital stay which is expected to be average 3 weeks
Mean BG After First Day of Hospitalization
Time frame: after first day of hospitalization
Number of Patients Developed Hypoglycemic Events
Hypoglycemic episodes are classified as major (BG ≤ 40 mg/dL or associated with impaired mental status or loss of consciousness), or minor (BG between 40 and 59 mg/dL) events.
Time frame: during hospital stay which is expected to be average 3 weeks
Number of Patients Developed Episodes of Severe Hyperglycemia
Hyperglycemic events are defined as BG \> 300 mg/dL.
Time frame: during hospital stay which is expected to be average 3 weeks
Mortality Rate
Time frame: during the hospital stay which is expected to be average 3 weeks
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