Repetitive Transcranial Magnetic Stimulation in Patients With Hemiplegic Stroke

Dongtan Sacred Heart Hospital48 enrolled

Overview

Stroke is one of the major causes of death in the World. Many stroke survivors may suffer from long-term sequelae of stroke such as hemiplegia. The effects of rehabilitation therapy are limited. The development of new treatment strategies is essential. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive method to stimulate the focal area of the brain for restoring brain function. The aim of this study is to investigate the therapeutic effect of rTMS on the motor recovery in patients with hemiplegic stroke.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Stroke

Interventions

Traditional Theta burst stimulation (TBS)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * stroke patients with motor weakness * Medical research council (MRC) grade 0-4 * More than 2 weeks after stroke onset * Age 18 years and older * Able to provide consent for the protocol Exclusion Criteria: * History of previous symptomatic stroke * pregnant women * Persons with surgically or traumatically implanted foreign bodies such as a pacemaker, an implanted medication pump, a metal plate in the skull, or metal inside the skull or eyes (other than dental appliances or fillings), intracardiac lines that may pose a physical hazard during magnetic stimulation will also be excluded * Patients with history of seizure disorder or epilepsy * Subjects without the capacity to give informed consent

Outcomes

Primary Outcomes

Keyboard tapping test

Participants will be asked to tap a key of a computer keyboard as fast as possible in five seconds. They will be asked to do three times. We will measure the number of tapping. The primary outcome will be the averaged data of the numbers.This will be done before and after 5-day rTMS intervention.

Time frame: 1 day

Central Contacts

Suk Yun Kang, MD, PhD

CONTACT

82-31-8086-2310 sukyunkang@hanmail.net

Ah-Young Jun, MD, MS