DESTINY TRIAL (Inspiron x Biomatrix)

Inclusion Criteria: 1. Age \> 18 years; 2. Symptomatic ischemic heart disease and / or objective evidence of myocardial ischemia with one or two target lesions located in different epicardial vessels; 3. A(s) lesion(s) to target(m) must be: 1. Again (not restenotic); 2. Located in a native coronary artery diameter from 2.5 to 3.5 mm (visual); 3. Can be treated with a single stent up to 29 mm in length; 4. Obstruction with stenosis \> 50% diameter (visual); 4. Acceptable candidate for CABG; 5. The patient will be informed of the nature of the study, agree with their rules and provide a written informed consent approved by the local Ethics Committee. Exclusion Criteria: 1. Women of childbearing age with no history of surgical sterilization; 2. Myocardial infarction with Q wave occurred in the last 48 hours before the index procedure; 3. Myocardial infarction with or without Q wave with cardiac markers even at high levels; 4. Ejection fraction \< 30%; 5. Impaired renal function (creatinine\> 2.0 mg / dl) or calculated creatinine clearance \< 60 ml / min; 6. Platelet count \<100,000 cells/mm3 or \> 700,000 cells/mm3; 7. Total leukocyte count \<3000 cells/mm3; 8. Documented or suspected liver disease (including laboratory evidence of hepatitis); 9. Heart transplant recipient; 10. Known allergies to aspirin, clopidogrel, ticlopidine, paclitaxel, sirolimus, heparin or stainless steel; 11. Patient with a life expectancy less than 12 months; 12. Any significant medical condition which in the opinion of the investigator would interfere with the ideal of patient participation in this study; 13. Participation in other research in the last 12 months, unless there is direct benefit to the research subject; 14. Coronary angioplasty (with or without stenting) for less than 6 months anywhere in the target vessel; 15. Coronary angioplasty (with or without stenting) prior to any time in that segment Diste less than 5 mm (proximal or distal) of the lesion; 16. Coronary angioplasty (with or without stenting) scheduled in the first 12 months after the index procedure in any segment of the target vessel. EXCLUSION CRITERIA angiographic 1. Restenotic target lesion; 2. Need for treatment for more than one lesion in the same vessel; 3. Need for treatment with three or more lesions in the same procedure; 4. Target vessel diameter \<2.5 mm or\> 3.5 mm (visual); 5. Target lesion long not susceptible to treatment with a single stent to 29mm in length, according to the judgment of the operator; 6. Lesion of the coronary artery unprotected ( \> 50% stenosis); 7. Angiographic thrombus; 8. Target lesion in surgical graft; 9. Total occlusion (TIMI anterograde flow 0 or 1); 10. Ostial lesion; 11. The target lesion bifurcation with side branch that may require intervention during the procedure, with or without stenting; 12. Injuries that are impossible to anticipate predilatation successfully or that is necessary to use rotablator; 13. The target vessel with excessive tortuosity.