The study is conducted to assess the effect of a vitamin D3 supplementation on the activities of two intestinal transporters and on the pharmacokinetics of the transporter substrates folic acid and fexofenadine. * Trial with medicinal product
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
10
University Hospital Zurich, Dept. of Clinical Pharmacology and Toxicology
Zurich, Canton of Zurich, Switzerland
Ratio of the area under the concentration vs. time curve (AUC) of fexofenadine after vitamin D over AUC of fexofenadine before vitamin D
Changes in single-dose pharmacokinetics of racemic fexofenadine at the end of a substitution with 1,25 dihydroxyvitamin D3 in comparison to pharmacokinetics before the substitution.
Time frame: 10 days
Ratio of Area under the concentration vs. time curve (AUC) of folic acid after vitamin D over AUC of folic acid before vitamin D
Changes in single-dose pharmacokinetics of folic acid at the end of a substitution with 1,25 dihydroxyvitamin D3 in comparison to pharmacokinetics before the substitution.
Time frame: 10 days
Number and characteristics of participants with adverse events
Time frame: 10 days
transporter mRNA quantity
Comparison of transporter mRNA levels after ten days of vitamin D3 intake in comparison to the levels before intake.
Time frame: 10 days
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