Effect of Meal Patterning on Carotenoid Absorption From Vegetables

Purdue University6 enrolled

Overview

The purpose of this research study is to determine how different meal patterns influence the absorption of beneficial plant pigments (carotenoids) from vegetables. The hypothesis is that carotenoid absorption will be lower when daily vegetables are consumed in one meal compared two smaller meals throughout the day.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

SINGLE

Enrollment

Conditions

Carotenoid Bioavailability Dietary Modification

Interventions

Meal Pattern Treatment AOTHER

In treatment A, subjects consumed 100% of salad vegetables and canola oil in the first meal and 0% in the second. Additional protein-rich "chef's salad" ingredients were distributed equally between meals.

Meal Pattern Treatment BOTHER

In treatment B, subjects consumed 50% of salad vegetables and canola oil in the first meal and 50% in the second. Additional protein-rich "chef's salad" ingredients were distributed equally between meals.

Meal Pattern Treatment COTHER

In treatment C, subjects consumed 75% of vegetables and oil in the first meal and 25% in the second. Additional protein-rich "chef's salad" ingredients were distributed equally between meals.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * Age range: 18-50 years * Body mass index (BMI: weight (kg)/height (m2)) ranging from 20-29 kg/m² * Weight stable (\<4.5 kg change within the last 3 months) * Constant habitual activity pattern, not to exceed activities of a recreational level over the past 3 months * Have clinically normal blood profiles (specifically normal liver and kidney functions and fasting blood glucose of ≤110 mg/dl) * Non-smoking * Non-diabetic * No current use of medication affecting lipid profile * No intestinal disorders including lipid malabsorption, lactose intolerance * No heavy consumption of alcohol (\>2 drinks per day) * No current use of dietary supplements that affect cholesterol, (e.g. Benocol or fiber supplements) or a willingness to discontinue their use during the study Exclusion criteria: * Diabetic * Use of lipid altering medications

Outcomes

Primary Outcomes

Area under the concentration (AUC) vs time curve for carotenoids in the triglyceride-rich lipoprotein (TRL) fraction of plasma.

Time frame: 0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12 hours post dose

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.