Comparative Study on the Effects of Epidural Dexmedetomidine on Heart Rate Variability During General Anesthesia in Patients Undergoing Gastrectomy

Yonsei University38 enrolled

Overview

The use of epidural dexmedetomidine decreases the anaesthetic requirements and improved postoperative pain. Dexmedetomidine is a potent and highly selective a2-adrenoceptor agonist and has sympatholytic effect. Power spectral analysis of heart rate variability(HRV) is a useful tool to assess cardiac autonomic activity. We investigated whether preemptive epidural dexmedetomidine can develop hemodynamic change and it could be identify patients by HRV.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

TRIPLE

Enrollment

Conditions

Gastric Cancer

Interventions

preemptive dexmedetomidine epidural bolus injection(1.5 mcg/kg)DRUG

Patients in the pre-emptive groups recived a dose of 1.5㎍/kg dexmedetomidine dissolved into normal saline 10cc before the induction of

normal salineDRUG

patients in the control groups received the equivalent volume of normal saline.

Eligibility

Sex: ALLMin age: 40 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients consented to spinal anesthesia were enrolled * Patients aged 40\~70 years olds undergoing gastrectomy * No contraindication of epidural analgesia * ASA class I and II * Patients consented to epidural anesthesia were enrolled Exclusion Criteria: * Patients with hypovolemia, coagulation disorders, local infection at the site of operation, history of headache, heart diseases, and history of allergy, chronic alcohol use or abuse, anemia, congenital heart diseases, bundle block, congestive heart failure or arrythmias * patients who had recently received sedative drugs or were under antidepressant treatment were not included in the study

Locations (1)

Department of Anesthesiology and Pain Medicine, and Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea

Seoul, Seoul, South Korea

Outcomes

Primary Outcomes

Heart rate variability analysis

Heart rate variability analysis was performed according to the Task Force recommendations. Frequency domain analysis was based on fast Fourier transformation. Power spectrum densities were calculated for low frequencies (LF: 0.04-0.15 Hz) and high frequencies (HF: 0.15-0.4 Hz) informalized units, defined as the LF or HF proportional part of the total power. Baseline and 30min after the injection of the study drug.

Time frame: 5min perioids after fluid resuscitation.

Secondary Outcomes

Epidural injection

And secondary data collection was done at 30 min after the epidural injection of the study drug. All of the HRV analysis was done before anaesthesia induction.

Time frame: at 30 min after the epidural injection of the study drug

Data from ClinicalTrials.gov

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