Effect of Omega-3 Fatty Acids on Insulin Sensitivity in Chinese Type 2 Diabetic Patients

Zhejiang University185 enrolled

Overview

This study is to examine the change of fasting insulin, glucose, insulin sensitivity and related traits in response to the six month treatment of omega-3 fatty acids, including fish oil and flaxseed oil, in Chinese type 2 diabetic patients. Corn oil, rich in omega-6 fatty acids, will be selected as a controlled oil. The investigators hypothesize that omega-3 fatty acids could improve insulin sensitivity and glucose metabolism in Chinese type 2 diabetic patients.

The insulin resistance will be estimated by a homeostatic model assessment model of insulin resistance (HOMA-IR)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

TRIPLE

Enrollment

185

Conditions

Type 2 Diabetes Insulin Resistance

Interventions

Fish Oil SupplementationDIETARY_SUPPLEMENT

Flaxseed Oil SupplementationDIETARY_SUPPLEMENT

placeboDIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 35 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Fasting glucose \> 7.0 or have diabetes medication; 2. Male, 35-80 years; female, postmenopausal to 80 years; 3. Agree to participant in the trial. Exclusion Criteria: 1. Deny to sign the informed consent; 2. type 1 diabetes; 3. Family history of hypertriglyceridemia or fasting triglyceride\>4.56 mmol/L; 4. Have severe liver disease, kidney disease or cancer; 5. Participating in the other clinical trial within 30 days; 6. Other diseases or conditions, for which the doctor of the patients do not agree his or her participating.

Locations (1)

Zhejiang University

Hangzhou, Zhejiang, China

Outcomes

Primary Outcomes

insulin resistance

Time frame: 180 days

Data from ClinicalTrials.gov

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