The purpose of this study is to determine whether the Biomarkers (pro adrenomedullin (MR proADM), pro arginin vasopressin (CT proAVP), pro atrial natriuretic peptid (MR proANP), Pro Endothelin) changes at Day 2, Day 5 and Day 7 of ICU admission are correlated with Intravascular volume assessed by Cr 51 on red blood cells (Day 2 and Day 7) and by I 125 on albumine Day 7. The correlation of these Biomarkers are also evaluted with other markers such as erythropoietin and catecholamines. 80 ICU patients are included.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
66
Hôpital Bicêtre
Le Krémilin Bicêtre, Île-de-France Region, France
Predictive value of biomarkers changes in Volemia variation
Correlation with total blood volume(assessed by Cr 51) and biomarkers(Mr proADM, Mr proANP, CT proAVP and proendothelin)changes
Time frame: at Day 2, Day 5 and Day 7 of ICU admission
Predictive value of biomarkers changes with efficient volemia, fluid managements and other Markers such erythropoietin
Correlation with efficient volemia and Biomarkers ( Mr proADM, Mr proANP, CT proAVP and proendothelin)changes.
Time frame: at Day 2, Day 5 and Day 7 of ICU admission
Predictive value of Biomarkers with APACHE II and SOFA score and Prognosis at ICU discharge
Correlation of Biomarkers changes with APACHE II and SOFA score and Mortality at Day 2, Day 5 and Day 7 of their ICU admission and at ICU discharge.
Time frame: at Day 2 , Day 5 and Day 7 of ICU admission and at discharge
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