Low blood sugar can negatively affect how blood vessels function, and this can lead to an increase in the risk for heart attacks, strokes and other problems related to the stiffening and blockage of blood vessels. The purpose of this study is to learn if and how glucagon-like peptide-1 (GLP-1; a naturally occurring hormone in the gut) changes the effects that low blood sugar levels have on blood vessels.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
28
GLP-1 infusion during experimental period
Saline infusion (placebo) during experimental period
University of Maryland, Baltimore
Baltimore, Maryland, United States
Change in Plasminogen Activation inhibitor-1 (PAi-1)
measurements of change in PAi-1 at baseline and during the end of the glucose clamp period (2 hours)
Time frame: change from baseline to end of clamp period
Change in Flow mediated dilation (FMD)
flow mediated dilation of the brachial artery will be measured for change from baseline and end of glucose clamp (\~4 hours)
Time frame: change from baseline and end of clamp
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