Evaluation and Comparison of Systemic Exposure to Ibuprofen After Single Oromucosal Versus Oral Administrations

Inclusion Criteria: * Healthy male subject aged 18 to 45 years (inclusive), * 18.5 \< or = Body Mass Index \< or = 30 kg/m², * Non-smoker for at least 6 months * Subject agreed to be registered in the Belgium national register "VIP Check International" for this study participation . Exclusion Criteria: * Positive serology for Hepatitis B Virus antigens, Hepatitis C Virus or Human Immunodeficiency Virus 1 or 2 antibodies, * Organic disorder likely to modify absorption, distribution or elimination of the medication, * History of sensitivity to ibuprofen or other NonSteroidal Anti-Inflammatory Drugs (NSAIDs) or to any of the excipients * Subject who has donated blood within the past 3 months, * Subject who has forfeited his freedom by administrative or legal award, or who is under guardianship or who has been admitted in a sanitary or social institution, * Participation in another clinical trial in the previous month or subject still within the exclusion period of a previous clinical trial or is participating in another clinical trial,