Safety, Pharmacokinetics and Pharmacodynamics of LGT209 in Healthy Volunteers With Elevated Cholesterol and in Hypercholesterolemic Patients Treated With Statins

Inclusion Criteria: * Healthy volunteers: Male and female subjects 18 to 70 years of age, in general good health with fasting LDL-cholesterol \>90 mg/dL and fasting serum triglycerides \<400 mg/dL * Patients on statin therapy: Male and female patients 18 to 70 years of age receiving atorvastatin or simvastatin and with fasting LDL-cholesterol \>90 mg/dL and fasting serum triglycerides \<400 mg/dL Exclusion Criteria: Healthy volunteers: * History of hypersensitivity to any of the study drugs or to drugs of similar chemical classes * Women of child-bearing potential unless using highly effective methods of contraception * Conditions which might impact the safety or biologic activity of the study drug Statin patients: * Use of concomitant medications known to impact the safe use or efficacy of atorvastatin and simvastatin based on drug labels * Women of childbearing potential unless using highly effective methods of contraception during dosing and for at least 100 days after study drug administration * Conditions which might impact the safety or biologic activity of the study drug Other protocol-defined inclusion/exclusion criteria may apply.