A Prospective Multicenter Study to Evaluate Usefulness of Cardio-Ankle Vascular Index in Japan

CAVI-J Study Group3,026 enrolled

Overview

The objective of this five-year prospective observational follow-up study is to examine the additional benefits of using cardio-ankle vascular index (CAVI) as a predictive indicator of cardiovascular events in high-risk patients.

Study Type

OBSERVATIONAL

Enrollment

3,026

Conditions

Stroke Cardiovascular Death Nonfatal Myocardial Infarction

Eligibility

Sex: ALLMin age: 40 YearsMax age: 74 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients between 40 and 74 years of age who have either of the following: 1. Type 2 diabetes mellitus 2. Metabolic syndrome 3. Grade I to III hypertension with the third layer of risk factors according to the guidelines for the management of hypertension japanese society of hypertension(JSH)2009 4. Chronic kidney disease(stage G3a or G3b) according ot the clinical Practice Guidebook for Diagnosis and Treatment of Chronic Kidney Disease 2012 in Japan 5. History of coronary artery disease or noncardiogenic cerebral infarction Exclusion Criteria: 1. Under 40 years of age or over 74 years of age 2. An ankle-brachial index less than 0.9 3. Chronic atrial fibrillation 4. Current symptoms of heart failure(NYHA class III or IV) or left ventricular dysfunction (EF below 40%) 5. Malignancy 6. Chronic kidney disease(G4 or G5)according ot the clinical Practice Guidebook for Diagnosis and Treatment of Chronic Kidney Disease 2012 in Japan 7. chronic dialysis due to renal failure 8. Taking steroids/immunosuppressants 9. Hepatocirrhosis

Locations (1)

Okayama University

Okayama, Japan

Outcomes

Primary Outcomes

major cardiac events

cardiac death, nonfatal myocardial infarction, stroke

Time frame: five years

Secondary Outcomes

all cause mortality, cardiovascular events, and renaly dysfunction

all cause death, angina pectoris (with revascularization), New incidence of lower limb peripheral arterial disease(including lower limb arteriosclerosis obliterans), Aortic aneurysm, Aortic dissection, Heart failure that requires hospitalization, Deterioration in renal function (dialysis or renal transplantation)

Time frame: five years

Data from ClinicalTrials.gov

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