Cranberry and cranberry-lingonberry juice prevented urinary tract infections in children and in adults in our earlier clinical trials. The preventive effect was, however, observed late in the follow-up and the next recurrence was not prevented in children. The investigators hypothesize that cranberry-lingonberry juice should be started already during the antimicrobial treatment of acute urinary tract infection in order to maximize the preventive efficacy of the juice. In addition, the investigators aim to find the explanation for the efficacy of cranberry-lingonberry juice by analyzing the concomitant changes in the chemical composition of urine and feces as well as the changes of gut microbiota.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
113
Juice iwth similar sugar concentration as cranberry-lingonberry juice but without berry extracts
Department of Pediatrics, University of Oulu
Oulu, Finland
Change of the intestinal and urinary microbiome
Time frame: 3 months to 12 months
The occurrence of urinary tract infections (infection episodes/person years at risk)
Time frame: 12 months
Time to the first recurrence
Time frame: 6 months
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