The project is aimed to develop predictive indices of spinal cord injury severity through the analysis of cerebrospinal fluid of patient collected during acute injury.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
10
The only intervention is the lumbar puncture on the patients to obtain a Cerebrospinal Fluid sample
Montecatone Rehabilitation Institute SpA
Imola, Bologna, Italy
Centro Interdipartimentale Ricerca Industriale Università degli Studi
Ozzano Monferrato, Bologna, Italy
UOC Rianimazione CO e 118 Ospedale Maggiore AUSL
Bologna, Italy
UOSD Chirurgia Vertebrale di Urgenza e del Trauma Ospedale Maggiore AUSL
Bologna, Italy
Creation of a model which analyze relationship among laboratory investigations and primary lesion, secondary damage and functional impairment
Correlation of the dosage of more than 20 tentative biomarkers with the biological effect of Cerebrospinal Fluid exposure on human cell lines, in order to directly test those effects. The Cerebrospinal Fluid will be encoded using technical procedures, divided into aliquots, quickly frozen and stored at 80°C. Biomarkers will be measured in the Cerebrospinal Fluid, related to: * inflammatory and vascular reaction, by a cytokine panel including 12 different cytokines/chemochines; * neurodegeneration and excitotoxicity, by a panel of 10 different biomarkers.
Time frame: Three years
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