Sepsis is a serious clinical condition with a considerable morbidity and mortality. Procalcitonin (PCT) is a good biomarker for early diagnosis and infection monitoring. The present study aimed to investigate the effect of semi-quantitative PCT test to the empirical antibiotic initiation time, the appropriateness of empirical antibiotics and mortality in septic patients. The hypothesis of the study are : * There is an effect on mortality between septic patients who do and do not do semi-quantitative PCT examination * There is an effect on empirical antibiotic initiation time between septic patients who do and do not do semi-quantitative PCT examination * There is an effect on appropriateness of empirical antibiotic between septic patients who do and do not do semi-quantitative PCT examination Study design is randomized diagnostic trial which is also a pragmatic trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Enrollment
205
Cipto Mangunkusumo Hospital
Jakarta, DKI Jakarta, Indonesia
mortality rate
mortality in 14 days since the patients were included in this study
Time frame: 14 days
the timing of empirical antibiotic first dose
when does the patient get their first dose of empirical antibiotic in 24 hours since the patient was diagnosis as sepsis?
Time frame: in 24 hours since the patient was diagnosis as sepsis
the appropriateness of empirical antibiotic
does the empirical antibiotic that given in 24 hours since the patient was diagnosis as sepsis is effective?
Time frame: in 24 hours since the patient was diagnosed as sepsis
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