This project focuses on the physiopathology of left ventricular remodeling associated with type II diabetes in patients with aortic valve stenosis referred for surgical aortic valve replacement. The main objective is to compare the reverse left ventricular remodeling between patients with type II diabetes and case-control patients without diabetes at one(1) year after surgical aortic valve replacement. The secondary objectives are : 1. assess the influence of type II diabetes on left ventricular remodeling in patients presenting with aortic valve stenosis, 2. assess the predictive value of myocardial fibrosis and other LV characteristics present prior to aortic valve surgery on the LV reverse remodeling and their influence on cardiovascular events at one (1) year after surgery, 3. assess the influence of type II diabetes on cardiovascular morbidity and mortality post aortic valve surgery. The investigators main hypothesis is that patients with type II diabetes and aortic valve stenosis requiring aortic valve replacement have poorer LV function and less favorable post surgery clinical outcomes than patients without type II diabetes.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Masking
NONE
Enrollment
100
* blood collection * Completion of a pre-operative cardiac MRI. * Completion of a coronary angiography examination * Completion during the surgery d'une myocardial biopsy, * Aortic echocardiographic follow-up (including post-operative ultrasound and ultrasound at 1 year * Completion of a cardiac MRI 1 year after surgery.
Hospices Civils de Lyon - Hôpital Louis Pradel
Lyon, France
RECRUITINGLeft Ventricular Mass measured by echocardiography
Time frame: Primary outcome is assessed at one year 1 year after aortic valve replacement.
cardiovascular events (cardiac mortality, heart failure, atrial or ventricular rhythm abnormalities) and clinical improvement (NYHA class, 6-minute walk test).
Time frame: 1 year after aortic valve replacement.
Measurement of BNP (Brain Natriuretic Peptide).
Time frame: 1 year after aortic valve replacement.
Echocardiographic parameters.
Left Ventricular Ejection Fraction, Systolic Longitudinal Strain, Systolic Circumferential Strain, Systolic Radial Strain, Diameters, wall thickness.
Time frame: 1 year after aortic valve replacement.
Magnetic Resonance Imaging (MRI) parameters.
LV mass, volumes, ejection fraction, replacement fibrosis mass on delayed enhanced studies, and interstitial fibrosis quantification (T1 mapping studies).
Time frame: 1 year after aortic valve replacement.
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