In order to investigate if individuals, carrying genetic variants predisposing to obesity, respond differently to visual presented food images than non-carriers the investigators aim to screen 500 people for a common risk variant in the FTO gene. From those 500 screened 40 subjects, 20 homozygous for the risk allele and 20 homozygous for a non risk allele will be selected for the second step in the study. This part involves the fMRI technique to visualize the brain response, focus on reward system activation, when food images are visually presented in the scanner. Factors regarding eating behavior, sleep, physical exercise and relation to food are investigated in the first part of the study as well as clinical parameters such as BMI.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
500
Blood sampling are performed at the initiation visit in order to screen for allele variants
Selective attention test where subjects, in one minute, names the ink color of several words without naming the word itself.
Functional Magnetic Resonance Imaging, performed to view brain activity
Uppsala University
Uppsala, Uppsala County, Sweden
RECRUITINGdep. Neuroscience, Uppsala University
Uppsala, Uppsala County, Sweden
RECRUITINGGenotyping for variants in the FTO gene associated with overweight and obesity
Time frame: Blood sampling for genetic analyse is performed at the initiation visit
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