Comparison of Analgesic Efficacy and Occurrence of Emesis Among Different Background Infusion and Bolus Administration Regimens of Fentanyl Based Intravenous Patient-controlled Analgesia in Patients After Laparoscopic Assisted Gastrectomy - a Randomized Blind Study -

Yonsei University225 enrolled

Overview

Fentanyl based intravenous patient controlled analgesia(PCA)is popular method for postoperative pain control, but information regarding optimal dose of fentanyl in IV PCA is currently lacking. We thus determine appropriate dose of fentanyl (bolus dose and background infusion rate) for effective pain control with minimal side effects such as nausea and vomiting

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

225

Conditions

The Patients With Gastric Cancer Who Are Scheduled to Receive Laparoscopy Assisted Gastrectomy

Interventions

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 20 and 70 * ASA class I and II * Gastric cancer patients who are scheduled to receive laparoscopic gastrectomy Exclusion Criteria: * Cardiovascular disease(uncontrolled hypertension, unstable angina, congestive heart failure, etc.) * Renal failure * Liver failure * Chronic drug or alcohol abuser * Anti-cancer chemotherapy * Chronic opioid use * Use of antiemetics within 24hrs for nausea and vomiting

Outcomes

Primary Outcomes

Pain score(VAS) within 48hrs after surgery

Pain score after surgery within 48hrs after laparoscopic gastrectomy

Time frame: Pain socre after surgery 1) within 30min-6hrs, 2) within 6-24hrs, 3) within 24hrs-48hrs