Misoprostol Versus Oxytocin for Prevention of Post Partum Hemorrhage

Hormozgan University of Medical Sciences400 enrolled

Overview

Post partum Hemorrhage (PPH) is one of three main causes of death in pregnant women. Oxytocin is widely used for prevention of PPH. Some studies suggested misoprostol as an alternative treatment when Oxytocin isn't available. The aim of this study is to compare the safety and efficacy of Oxytocin and misoprostol for prevention of PPH.

In a double blind randomized controlled trial 400 pregnant women who has vaginal delivery at Shariati hospital are assigned into two groups either to receive 20 unite oxytocin in 1000cc ringer and 2 placebo tablet or 400mcg oral misoprostol and 2cc normal saline in 1000cc ringer.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

400

Conditions

Post Partum Hemorrhage

Interventions

MisoprostolDRUG

400µg oral misoprostol

OxytocinDRUG

20 IU Oxytocin

Eligibility

Sex: FEMALEMin age: 10 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * were women with singleton pregnancy * with cephalic presentation * who had NVD spontaneously or by induction Exclusion Criteria: * placenta previa * placental detachment * coagulation problems * previous CS * macrosomia * Polyhydramnios * and uncontrolled asthma

Locations (1)

Hormozgan University of Medical Sciences

Bandar Abbas, Hormozgan, Iran

Outcomes

Primary Outcomes

Amount of bleeding

within 1 hours after delivery

Time frame: 1 hour

Secondary Outcomes

Hemoglobin decrease

Time frame: 24 hours

Hematocrite decrease

Time frame: 24 hours

Data from ClinicalTrials.gov

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