From clinical observation that some achalasia patients drink water to help swallow food, the investigators have proposed a systemic hot water drinking therapy. This study is to observe its efficacy on achalasia symptoms and explore its mechanism.
1. Achalasia patients will participate hot water drinking therapy: to drink 200ml of hot water before and after a meal, as well as 2 hours before sleep and to chew food carefully and swallow with hot soup. 2. Patients are followed by achalasia associated symptom scores, barium esophagram and endoscopy. 3. If patients are unsatisfied with hot water drinking therapy, they receive pneumatic dilation
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Drink 200ml hot water 3min before and after a meal. Swallow food with hot water and drink 200ml hot water before sleep
Patients who are unsatisfied with hot water drinking therapy are to receive standard pneumatic dilation under endoscope
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science
Beijing, China
RECRUITINGChange from baseline achalasia symptom score at 1 month
Dysphagia, Regurgitation and Chest Pain scores
Time frame: baseline and 1 month
Number of patients with adverse effects
adverse effects of drinking water like distention, nausea and belching
Time frame: Week 1
Change from baseline in barium esophagram at 1 year
measure esophageal diameter
Time frame: baseline and 1 year
Endoscopy at 1 year
esophageal bezoars and esophageal cancer
Time frame: year 1
Pneumatic dilation rate and relative efficacy
Patients who are unsatisfied with hot water drinking therapy are to receive pneumatic dilation
Time frame: any time
Change from baseline in achalasia symptom score at 1 year
Dysphagia,Regurgitation and Chest Pain scores
Time frame: baseline and 1 year
Change from baseline achalasia symptom scores at 5 years
Dysphagia,Regurgitation and Chest Pain scores
Time frame: baseline and 5 years
Change from baseline in barium esophagram at 5 years
measure esophageal diameter
Time frame: baseline and 5 years
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Endoscopy at 5 years
esophageal bezoars and esophageal cancer
Time frame: year 5