The purpose of this study is to test the hypothesis that the onset of the antiplatelet effect of ticagrelor is more rapid and greater than clopidogrel in Chinese patients with ACS.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
90mg tablets. loading dose of 180mg ticagrelor tablets (two 90mg tablets) taken orally, followed by 90mg of ticagrelor 12 hours after the first dose. Duration of treatment: 6 weeks.
75mg capsule. loading dose of 600mg clopidogrel capsules (eight 75mg capsules) taken orally, follow by 75mg of clopidogrel capsules orally od. Duration of treatment: 6 weeks.
Research Site
Beijing, China
Research Site
Shenyang, China
Research Site
Tianjin, China
the Percentage Inhibition of the P2Y12 Receptor
Note: the primary endpoint was changed per the statistical analysis plan prior database lock.
Time frame: at 2 hours after first dose of study drug
the Percentage Inhibition of the P2Y12 Receptor
Time frame: at 0.5 hour after first dose of study drug
the Percentage Inhibition of the P2Y12 Receptor
Time frame: at 8 hours after first dose of study drug
the Percentage Inhibition of the P2Y12 Receptor
Time frame: at 24 hours after first dose of study drug
the Percentage Inhibition of the P2Y12 Receptor
Time frame: at 6 weeks after first dose of study drug
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