Lutonix Global SFA Registry

Inclusion Criteria: * Male or non-pregnant female ≥18 years of age; * Rutherford Clinical Category ≤ 4; * Patient is willing to provide 5-year informed consent and comply with the required follow up; * Stenotic or obstructive vascular lesions of the femoropopliteal artery; * Lesion(s) can be treated with available LUTONIX Drug Coated PTA Dilatation Catheter device size matrix per current IFU; * At least one patent native outflow artery to the ankle free from significant lesion (≥50% stenosis) as confirmed by angiography (treatment of outflow disease is NOT permitted; treatment of in-flow disease is permitted prior to treatment with the LUTONIX Drug Coated PTA Dilatation Catheter). Exclusion Criteria: * Patient is currently participating in an investigational drug or device study; * Inability to take recommended medications as stated in the IFU or non-controllable allergy to contrast; * Pregnant or planning on becoming pregnant or men intending to father a child; * Rutherford Class \> 4 * Known inadequate distal outflow or planned future treatment of vascular disease distal to the target lesion