Assessment of Optic Nerve Radiation in Patients With Glaucoma and Ocular Hypertension by 7 Tesla Diffusion Tensor Imaging

Inclusion Criteria: Healthy controls * Men and women aged over 18 years * Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant * Normal ophthalmic findings Patients with ocular hypertension * Men and women aged over 18 years * Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant * Normal ophthalmic findings except presence of ocular hypertension (defined as untreated IOP ≥ 21 mmHg on at least three measurements in the medical history, no signs of glaucomatous damage in the optic disc or the glaucoma hemifield test) Patients with primary open angle glaucoma * Men and women aged over 18 years * Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant * Diagnosis of manifest primary open angle glaucoma (defined as pathological optic disc appearance, glaucoma hemifield test outside normal limits and untreated IOP \> 20 mmHg on at least three measurements in the medical history) * Mean Deviation in the visual field test ≥ 10dB Patients with normal-tension glaucoma * Men and women aged over 18 years * Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant * Diagnosis of normal-tension glaucoma (defined as pathological optic disc appearance, glaucoma hemifield test outside normal limits and untreated IOP ≤ 20 mmHg on at least three measurements in the medical history) * Mean Deviation in the visual field test ≥ 10dB Exclusion Criteria: * Symptoms of a clinically relevant illness in the 3 weeks before the first study day * Presence or history of a severe medical condition as judged by the clinical investigator * Abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study * Exfoliation glaucoma, pigmentary glaucoma, history of acute angle closure * Intraocular surgery within the last 6 months * Ocular inflammation or infection within the last 3 months * Pregnancy, planned pregnancy or lactating * Any metallic, electric, electronic or magnetic device or object not removable except dental fillings * Claustrophobia