Restoring Vision With the Intelligent Retinal Implant System (IRIS V1)in Patients With Retinal Dystrophy

Inclusion Criteria: * Is 25 years or older at the date of enrolment * Has a confirmed diagnosis of retinitis pigmentosa, choroideremia or cone-rod dystrophy * Has a visual acuity of logMAR 2.3 or worse in both the eyes as determined by a Square Grating scale. * Has functional ganglion cells and optic nerve activity * Has a memory of former useful form vision * Understands and accepts the obligation to present for all schedule follow-up visits. * Has AP eye dimensions that are appropriate with the dimensions of the implant(In Germany: Has an AP eye dimension between 20.5 and 25 mm) * Has head dimensions that are appropriate for visual Interface. Exclusion Criteria: * Has a history of severe glaucoma, uveitis, optic neuropathy or any confirmed damage to the optic nerve and/or visual cortex, * Has any disease (other than study allowed diseases) or condition that affects retinal function of the study eye (e.g., central retinal artery/vein occlusion, end-stage diabetic retinopathy, current or prior retinal detachment, infectious or inflammatory retinal disease, etc.), * Has any disease or condition that prevents adequate visualization of the retina of the study eye including, but not limited to, corneal degeneration that cannot be resolved prior to implantation, * Has any disease or condition of the anterior segment of the study eye that prevents adequate physical examination (e.g., ocular trauma, etc.), * Has severe nystagmus, * Has any ocular condition that leads him or her to eye rubbing, * Has any disease or condition that precludes the understanding or communication of the informed consent, study requirements or test protocols (e.g., deafness , multiple sclerosis, amyotrophc lateral sclerosis, neuritis, etc), * Has a history of epileptic seizure, * Has a history of chronic or recurrent infection or inflammation that would preclude participation in the study, * Has a known sensitivity to the contact materials of the implant, * Presents with hypotony in the study eye, * Presents with hypertony in the study eye, * Is pregnant or lactating, * Has another active implanted device (e.g. cochlear implant) or any form of metallic implant in the head (other than dental work) that may interfere with the device function, * Has a diagnosis requiring an active implant (e.g., cardiac pacemaker, vagus nerve implant, etc.), * Has active cancer or a history of intraocular, optic nerve or brain cancer and metastasis, * Is an immune-suppressed subject (e.g., due to HIV positive diagnosis, etc.), * Is carrier of multi-resistant germs, * Requires the use of any of the following medications: * Antimetabolites, * Thrombocyte aggregation reducing therapies (10 days prior until 3 days after surgery), * Oral anticoagulants (5 days before until 3 days after surgery), * Is participating in another investigational drug or device study that may interfere with the proposed treatment or the ensuring follow-up schedule, (in Germany: Is participating in another investigational drug or device study) * Has any health concern that makes general anaesthesia inadvisable, (in Germany: Patients with an ASA-Score of 3 or higher are excluded from the study) * Is likely requiring MRI scans subsequent to implantation and prior to explantation, * Is likely requiring therapeutic ultrasound subsequent to implantation and prior to explantation of the Retinal Implant In Germany: - Patients with recurrent or chronic inflammations or infections are excluded from the study. Specifically patients with the following disorders are excluded: * Common inflammation - severe chronic and consuming diseases that frequently associated with infection (e.g. Crohn disease, Whipple's disease) * Chronic inflammation of the skin in the area of the eye (e.g. dermatitis, rosacea, infection of the skin, herpes zoster) * Chronic inflammation in the area of the eye (e.g. herpes of cornea and/or conjunctiva, recurrent blepharoconjunctivitis, horedolum, chalazion) In Germany: - Has a severe psychological disorder. When in any doubt, an expert assessment needs to be arranged to clarify whether the patient's psychological health is suitable for the trial. In Germany: - Has severe renal, cardiac, hepatic etc. organ diseases