Acupuncture or MBSR for Patients With Fatigue and MS

Inclusion Criteria: * female or male * 18 to 65 years of age * able to give oral and signed written informed consent * clinical diagnosis of multiple sclerosis * fatigue in "multiple sclerosis" for at least 3 months * other stable pre-study treatment with respect to target symptom fatigue for at least 3 months before inclusion * stable immunomodulatory or immunosuppressive therapy or stable no such a therapy for at least the 3 months before inclusion * fatigue score of ≥4 on the Fatigue Severity Scale at inclusion * patient's mental and physical ability to participate in the trial * willingness to be randomised, to attend visits, to complete questionnaires, and willingness to participate and fMRI measurements Exclusion Criteria: * fatigue because of a malignant disease * acute relapse or cortisone therapy therapy in the last 30 days before inclusion * EDSS (Extended disability status scale) \> 6 * fatigue specific acupuncture in the last 12 months * during the last 12 months performing of MBSR exercises learnt in the past * change of immunomodulatory or immunosuppressive therapy during the 3 months before inclusion * other new therapies are planned which could have a positive effect on fatigue (e.g. exercise, acupuncture, relaxation therapy) * for female patients: pregnancy or anticipated pregnancy during the intervention period * severe acute and or chronic disease which does not allow participation in the therapy * other limitations which do not allow participation in the therapy * alcohol or substance abuse * parallel participation in another clinical trial * BDI \> 29 * contra indications for fMRI session (e.g. metal clips)