The objective of the study is to assess the effect of motor, non-motor and genetic factors on the progression of Parkinson's disease as well as its impact on complications rates. A large sample of Mexican subjects with Parkinson's disease attending several referral centers will be included. Data collected will include disease severity and motor scales, non-motor scales as well as genotyping for monogenic forms of the disease. Assessments will be performed every 6 months for two years.
Demographic and clinical data will be collected after obtaining a signed informed consent. Recruitment will be competitive. Data collected includes age, gender, motor phenotype, age at onset, age at diagnosis, smoking history, family history, antiparkinsonic treatment, other treatments and a complete neurological evaluation.
Study Type
OBSERVATIONAL
Enrollment
550
Hospital Civil de Guadalajara
Guadalajara, Jalisco, Mexico
Hospital General de México
Mexico City, Mexico City, Mexico
Instituto Nacional de Neurología y Neurocirugía
Mexico City, Mexico City, Mexico
Hospital Universitario
Monterrey, Nuevo León, Mexico
Hospital Universitario
San Luis Potosí City, San Luis Potosí, Mexico
Hospital Regional #1
Mérida, Yucatán, Mexico
Hospital General de Zacatecas
Zacatecas City, Zacatecas, Mexico
To assess motor scale change over time
Motor symptoms will be assessed by proper and validated motor scales; also minimal clinically important change will be determined.
Time frame: Every 6 months for 2 years
To assess non-motor symptoms over time
Non-motor symptoms will be assessed using proper validated scales. Frequency and severity will be recorded.
Time frame: Every 6 months for 2 years
To assess quality of life change over time.
Health-related quality of life will be assessed with proper validated clinimetric instruments.
Time frame: Every 6 months for 2 years
To assess caregiver burden as disease progresses
Caregiver burden will be assessed by proper validated scales.
Time frame: Every 12 months for 2 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.