The purpose of this observational study is to evaluate the baroreceptor function in relation to surgical inflammation and orthostatic intolerance after elective hip arthroplasty. The main hypothesis is that baroreceptor function is attenuated after surgery and related to surgical inflammation.
Orthostatic intolerance and hypotension is prevalent during early mobilization after major surgery. This observational study aims to evaluate the baroreceptor function during using a standardized evaluation protocol before, 6- and 24 hours after elective primary unilateral hip-arthroplasty. The study hypothesis is that baroreceptor function as expressed by the valsalva ratio is attenuated after surgery and related to surgical inflammation.
Study Type
OBSERVATIONAL
Enrollment
30
Frederiksberg Hospital, Department of orthopaedic surgery
Frederiksberg, Denmark
RECRUITINGChange in baroreceptor function from preoperatively to 6 hours after surgery
Change in baroreceptor function as expressed by change in the blood pressure valsalva ratio during a standardized assessment before and 6 hours after surgery.
Time frame: 6 hours after surgery
Orthostatic response in blood pressure
The response in systolic and diastolic blood pressure during postural change from supine to standing
Time frame: Preoperative, 6 and 24 hours after surgery
Orthostatic response in heart rate variability
Heart rate variability during supine rest, sitting and standing as assessed by Spectral analysis.
Time frame: preoperative, 6 and 24 hours postoperative
Orthostatic intolerance
Orthostatic intolerance defined as the inability to sit or stand for 3 minutes due to presyncopal symptoms (Dizziness, Nausea, Blurred vision).
Time frame: preoperative, 6 and 24 hours after surgery
Inflammatory markers
Inflammatory markers (CRP and interleukin-6) measured at 3 separate timepoint: preoperative, 6- and 24 h after surgery
Time frame: preoperative, 6 and 24 hours postoperative
Orthostatic Hypotension
orthostatic hypotension defined according to international guidelines.
Time frame: Preoperative, 6 and 24 hours postoperative.
Baroreceptor function
baroreceptor function as expressed by change in the blood pressure valsalva ratio during a standardized assessment
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Time frame: On the day of surgery: preoperatively, 6- and 24 hours after surgery