Nordic 8 - A Phase II Trial

Inclusion Criteria: Histology and stages: * Histologically proven adenocarcinoma in the colon or rectum * At least 1 measurable metastatic disease manifestation according to the RECIST criteria (version 1.1) * Potentially completely resectable or potentially curable metastatic colorectal cancer as determined by the local MDT conference and that requires tumour shrinkage before resection is possible. The following definitions are indicative: * 4 or more liver metastases (CRLeM) without extra-hepatic disease * 2 or more lung metastases (CRLuM) without hepatic or extra-hepatic disease * 1 or more CRLeM determined as "potentially resectable" (such as because of location) by the local MDT. * 1 or more CRLuM determined by the local MDT as potentially resectable (such as because of location). * Non-resectable primary disease with resectable CRLeM or CRLuM. KRAS and BRAF status: \- Tumour tissue (primary or metastasis) typed as wild-type KRAS AND wild-type BRAF General conditions: * age \> 18 years * WHO performance status ≤ 1 * expected survival \> 3 months * sufficient bone-marrow function (Hb ≥ 6.2 µmol/l/Hb \> 10 g/dl ANC ≥ 1.5 x 109/l, thrombocytes ≥ 100 x 109/l) * sufficient kidney and liver function: total bilirubin ≤ 1.5 x upper normal limit, serum creatinine ≤ 1.25 x upper normal limit, ALAT ≤ 3 x upper normal limit and ≤ 5 x upper normal limit with liver metastases * the patient must have signed an informed declaration of consent before being registered; this must be documentable according to national guidelines Exclusion Criteria: Previous treatment: * previous chemotherapy for advanced/metastatic disease * adjuvant chemotherapy unless completed more than 6 months before registration * previous treatment with oxaliplatin or irinotecan * previous treatment with cetuximab or other treatment for EGFR * History of Inflammatory Bowel disease * Severe or uncontrolled cardiovascular disease, congestive heart failure NYHA III or IV, unstable angina pectoris, history of myocardial infarction within the last twelve months, significant arrhythmias) * Any condition that, according to the treating physician's judgement, could prevent the planned medical/surgical treatment from being carried out responsibly (such as uncontrolled active infection, known hypersensitivity or contra-indication for the planned treatment. * Pregnant or breast-feeding women * Patients of fertile age who do not want to use reliable contraception