A randomized multicentric parallel arms study involving the use of ketamine for treatment-resistant depression will be held at three national health provider clinics in the Mexican population. The purpose of this study is to determine whether clinical response seen in previous studies is replicable in this population.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
60
ABC Neurological Center
Mexico City, Mexico City, Mexico
RECRUITINGChanges in baseline HDRS Score
The Hamilton Depression Rating Scale (HDRS) baseline score will be measured 20 minutes before ketamine infusion. After 40 minutes post-infusion, a second HDRS score will be obtained.
Time frame: 20 minutes before and 40 minutes after ketamine infusion.
Daily change in HDRS post-ketamine infusion.
On a daily basis, from day 1-7 post-ketamine infusion, changes in HDRS score will be measured during the daily psychiatric evaluation.
Time frame: 1,2,3,4,5,6 and 7. Days after ketamine infusion
Baseline blood pressure (BP).
Baseline BP will be measured during the physical examination 20 minutes before ketamine infusion.
Time frame: 20 minutes before ketamine infusion.
Changes from baseline in blood pressure (BP)
BP will be monitored continuously for a 4-hour period. BP assessments will be taken every five minutes for the period mentioned. The assessment will start 20 minutes before ketamine administration and will finish 4hrs after starting.
Time frame: every 5 minutes in a 300 minutes period
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