The purpose of this study is to evaluate pharmacodynamic drug interaction between cilostazol and statins (simvastatin as a CYP3A substrate and rosuvastatin as a non-CYP3A substrate) in healthy male subjects.
Subjects suitable for this study will visit to the Clinical Trial Center, Samsung Medical Center for 7 days and pharmacodynamic samplings will be performed following the administration of study drugs.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
63
cilostazol bid for 7 days
simvastatin qd for 7 days
rosuvastatin qd for 7 days
Samsung Medical Center
Seoul, South Korea
lipid lowering effect
lipid panel
Time frame: 7 days
anti-platelet effect
platelet aggregation test
Time frame: 7 days
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