Safety/Tolerability and Pharmacokinetics/Pharmacodynamics of YH12852 After Oral Administration in Healthy Male Subjects

Inclusion Criteria: * healthy male/female aged 19 to 45 with body mass index(BMI) between 18 and 25kg/m2 * Subject who has no congenital, chronic disease and disease symptoms in medical examination result * Subject who is judged to be eligible by principal investigator or sub-investigator according to various reasons including their abnormal test results(clinical laboratory test, 12-lead ECG etc) * Subjects who has signed a written informed consent voluntarily,prior to any procedure, using a form that is approved by the local Institutional Review Board after detail explanation of the purpose, contents, and characteristic of the drug Exclusion Criteria: * Subject who has history or presence of clinically significant diseases in liver, kidney, gastrointestinal tract, nervous system, respiratory system, endocrine system, blood tumor, cardiovascular, urinary system, and mental disorder * Subject who is hypersensitive to components contained in YH12852 or prucalopride or aspirin/antibiotics like drugs * Medical history of gastrointestinal disease or acid restraining surgery, gastric/ esophagus surgery(excluding appendectomy, hernia surgery) * Clinically significant abnormal values in diagnostic check within 28 days before the treatment(\>1.25 fold of normal upper limit in the levels of AST or ALT, \>1.5 fold of normal upper limit in the levels of Total bilirubin, \< 80ml/min of Cockcroft-Gault used creatinine clearance * Subject has over QTc interval of 550 ms or PR interval of 210 ms or QRS interval of 120 ms or QT interval of 500 ms on baseline 12-lead ECG, as determined by the Investigator * Subject who had taken usual dose of any prescription drugs within 14 days before the treatment or who had used usual dose of OTC drugs within 7 days before the treatment * Subject who participated in another clinical trail within 2 months before enrolling in this study * subject who donated whole blood within 2 months or component blood within 1 month before the treatment * Medically unacceptable contraception used during the clinical trial * Subject who drank over 30g/day or were detected alcohol positive on test * Subject who stopped smoking within 3 months before the treatment or weren't able to stop smoking during the hospitalization * Subject who had a beverage containing caffeine during the hospitalization * Subjects with clinically significant observations considered as unsuitable based on medical judgment by investigators