Lower body negative pressure (LBNP) is a laboratory model used to study hemorrhage in humans. The investigators hypothesize that the physiologic changes that occur with application of LBNP mimic those observed in bleeding and hemodynamically unstable trauma patients, and that LBNP is a truly valid model of human hemorrhage.
Specific aims: 1. Compare physiologic waveform data obtained from bleeding and hemodynamically unstable trauma patients to existing data collected from LBNP subjects. 2. Determine the accuracy of LBNP in approximating the physiologic changes that occur in bleeding and hemodynamically unstable trauma patients.
Study Type
OBSERVATIONAL
Enrollment
50
Children's Hospital Colorado
Aurora, Colorado, United States
Denver Health Medical Center
Denver, Colorado, United States
San Antonio Military Medical Center
San Antonio, Texas, United States
Waveform data comparison
Compare physiologic waveform data obtained from bleeding and hemodynamically unstable trauma patients to existing data collected from LBNP subjects.
Time frame: Up to 12 months
Approximation accuracy
Determine the accuracy of LBNP in approximating the physiologic changes that occur in bleeding and hemodynamically unstable trauma patients.
Time frame: Up to 12 months
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