Safety Study of Bone-marrow Derived Mesenchymal Stromal Cells Associated With Endobronchial Valves in Emphysema

Inclusion Criteria: * Diagnosis of severe heterogeneous emphysema (heterogeneity \> 15%), with heterogeneity defined as the difference between lobes in the percent area covered by parenchymal density greater than -950 Hounsfield Units. * Estimation of collateral ventilation based on fissure with integrity ≥ 75%. * Total lung capacity\> 100% predicted. * Residual volume\> 150% predicted. * Forced expiratory volume at the first minute \<45% predicted. * Diffusing capacity of the lungs for carbon monoxide \<45% predicted. * Optimal medical treatment. * Limitations in daily physical activities. * Minimum of 4 months without smoking * Having family support. * Stage ≥ 2 in modified Medical Research Council Dyspnea Scale (MMRC). Exclusion Criteria: * Homogenous emphysema. * Presence of collateral ventilation. * Use of systemic corticosteroids (prednisone\> 20mg/day or equivalent). * Pulmonary or extrapulmonary infection. * Coronary heart disease and/or severe ventricular dysfunction. * Significant renal or liver disease. * Immunosuppressive disease. * Active smoking. * Cancer prognosis with survival \<2 years. * Psychosocial problems. * Pregnancy.