The overall aim with this project is to investigate the effect of dexmedetomidine on control of breathing in healthy volunteers and to compare it with propofol at the same degree of sedation.
15 volunteers will be investigated for their hypoxic and hypercapnic ventilatory response during sedation with dexmedetomidine and propofol in a randomized cross-over study. 6 volunteers will be investigated for their repeated response to hypoxia and hypercapnia in order to validate the method.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
11
Department of Anesthesiology, Surgical Sciences and Intensive Care Medicine, Karolinska University Hospital
Stockholm, Sweden
Hypoxic ventilatory response
Acute hypoxic ventilatory response,i.e. the ventilatory response to acute hypoxia measured as change in minute ventilation over change in peripheral oxygen saturation
Time frame: One day for each drug; before,during and after sedation with dexmeditomidine or propofol
hypercapnic ventilatory response
The acute ventilatory response to hypercapnia, i.e. change in minute ventilation over change in end-tidal carbon dioxide
Time frame: One day for each drug; Before, during and after sedation with dexmedetomidine or propofol
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