Intra-articular Corticosteroid Injection Compared With Single-Shot Hyaluronic Acid for Treatment of Osteoarthritis Knee

Thammasat University100 enrolled

Overview

Corticosteroid and Hylan G-F 20 are both effective in improving pain and function of osteoarthritic knee patients.

Corticosteroid and Hylan G-F 20 are both effective in improving pain and function of osteoarthritic knee patients up to 6 months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

100

Conditions

Knee Osteoarthritis

Interventions

Hylan G-F 20DRUG

After full aseptic preparation, Single shot intra-articular injection either 6 mL of Hylan G-F 20 or 1 mL of 40 mg triamcinolone acetonide plus 5 mL of 1% xylocaine with adrenaline were injected into the joint cavity using the infero-lateral approach via a 21-gauge needle.

CorticosteroidDRUG

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of knee OA * Knee pain for most days of the prior month * Radiographic evidence consistent with knee OA * Aged between 40 and 80 years old Exclusion Criteria: * Lumbar spondylosis * Gross deformity of the knee * Co-existent inflammatory or crystal arthritis * Prior knee surgery * Injury to the knee in the preceding 6 months * Any intra-articular injection in the preceding 3 months * Pregnant or Lactating * Current infection in the affected knee * Inability to provide informed consent

Locations (1)

Thammasat University Hospital, Thammasat University

Prathumthani, Changwat Pathum Thani, Thailand

Outcomes

Primary Outcomes

WOMAC Score

Change from Baseline in WOMAC score at 6 months

Time frame: 6 months

Secondary Outcomes

Visual Analogue Scale(VAS)

Change from Baseline in VAS score at 6 months

Time frame: 6 months

Data from ClinicalTrials.gov

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