Study of Immune Tolerance and Capacity for Wound Healing of Patients With Recessive Dystrophic Epidermolysis Bullosa (RDEB)

Inclusion Criteria: * Confirmed molecular diagnosis of recessive dystrophic epidermolysis bullosa, established for both alleles; * Non severe generalized clinical form of RDEB; * Presence of type VII collagen on skin biopsy and/or western-blot analysis detected with a set of specific antibodies; * Presence of intact skin areas without blisters, infection or erosion; * Absence of hospitalization related to EB condition; * Patients and their parents when applicable should be able and willing to return for follow up; * Patients should be able and willing to give signed informed consent. For patients who are minor, informed consent will be signed by a legally authorized representative, as well as an assent form by the minor patient. * Ability to undergo local anesthesia. Exclusion Criteria: * Severity of disease and presence of ill-prognostic features: 1. Premature termination codon in the noncollagenous (NC1) domain of COL7A1 on both alleles; 2. Absence of detectable type VII collagen expression on skin biopsy and Western blot analysis from cultured cells; * Underlying conditions, diseases or active infections likely to increase the risk of complications or to interfere with the biological investigations: 1. History of current or previous skin cancer (Squamous cell carcinoma or other malignant skin cancer); 2. Current infectious diseases, including systemic infections and known positive HIV serology (Kaposi's sarcoma), hepatitis B and C; 3. History of current psychological or psychiatric disease; 4. Absence of an adequate familial and social support; 5. History of current or previous organ diabetes mellitus; 6. Non corrected severe anemia (Hemoglobin level: \< 8 g/ml); 7. Non corrected iron deficiency; 8. History of significant allergy to an anaesthetic procedure 9. Patient currently receiving anticoagulant or anti-aggregation treatment; 10. Participation in another clinical trial or therapy protocol for RDEB at the time of study inclusion 11. Positive pregnancy urinary test or lactating women * Not affiliated to the national social security/health service beneficiary and families with beneficiary children.