Human Irisin Concentration in Sarcopenia

Korea University406 enrolled

Overview

Irisin has been identified as a novel myokine that drives brown-fat-like conversion of white adipose tissue. In this cross-sectional study, the researches investigated whether serum irisin levels are decreased in patients with sarcopenia compared with control subjects with normal muscle mass, and assessed the association between serum irisin levels and various metabolic parameters.

Study Type

OBSERVATIONAL

Enrollment

406

Conditions

Sarcopenia

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 20\<age\<80 * apparently healthy subjects Exclusion Criteria: * a history of cardiovascular disease * diabetes * stage 2 hypertension * malignancy * severe renal or hepatic disease

Locations (1)

Korea University Guro Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Serum concentration of irisin in the subjects with sarcopenia

Time frame: 12 week

Secondary Outcomes

The relationship of serum irisin levels with lipid profiles

Time frame: 12 week

The relationship of serum irisin levels with skeletal muscle mass index

Time frame: 12 wks

Data from ClinicalTrials.gov

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