Oral Glucose Stimulation in Normal-weight and Obese Volunteers

University Hospital, Basel, Switzerland24 enrolled

Overview

The objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in normal-weight and obese patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Endocrine System Diseases

Interventions

PlaceboDIETARY_SUPPLEMENT

Glucose 25gDIETARY_SUPPLEMENT

Glucose 10gDIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy normal weight subjects with a body-mass index of 19.0-24.5 or healthy obese subjects with a body-mass index of \> 30 * Normal eating habits * Age 18-40 years * Stable body weight for at least three months Exclusion Criteria: * Smoking * Substance abuse * Regular intake of medications (except for oral contraceptives) * Medical or psychiatric illness * Any abnormality detected during the screening procedure * history of gastrointestinal disorders * food allergies

Locations (1)

University Hospital Basel

Basel, Switzerland

Outcomes

Primary Outcomes

Effect of different oral glucose loads on secretion of satiation hormones

Plasma concentrations of glucose, insulin, glucagon, ghrelin, GLP-1, PYY and CCK are measured

Time frame: 240min.

Secondary Outcomes

Effect of different oral glucose loads on gastric emptying

measured by C13 breath test

Time frame: 240min.

Data from ClinicalTrials.gov

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