Comparison of Dietary Fats on Vascular Parameters

Unity Health Toronto24 enrolled

Overview

The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels. It is hypothesized that butter will have the most detrimental effect on acute vascular function. Canola, grapeseed and chia oil with their decreased content of SFA are hypothesized to impair vascular function to a lesser extent.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

TRIPLE

Enrollment

Conditions

Healthy

Interventions

Coconut OilOTHER

Shake with 50 g Coconut oil

Canola OilOTHER

Shake with 50 g Canola oil

Grapeseed OilOTHER

Shake with 50 g Grapeseed oil

Chia Oil

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * Age 18-65 years * BMI \< 30 kg/m2 * Brachial systolic blood pressure ≤ 140 mmHg * Brachial diastolic blood pressure ≤ 90 mmHg Exclusion Criteria: * Women of childbearing age must not be pregnant or breastfeeding at the time of the study * BMI \>35kg/m2 * Hypertensive as defined by brachial SBP \>140mmHg and/or DBP \>90mmHg * Sensitivity to the study product or its sources * Presence of chronic conditions or illnesses * Having any gastrointestinal complication or condition * Chronic use of dietary supplements that alter fat absorption

Locations (1)

Risk Factor Modification Centre, St. Michael's Hospital

Toronto, Ontario, Canada

RECRUITING

Outcomes

Primary Outcomes

To compare 5 different dietary fat sources in a liquid meal on postprandial changes in augmentation index (AIx)

Time frame: 5 separate mornings, measurements taken at baseline and at 60, 120 and 180 minutes

Secondary Outcomes

To investigate whether these dietary fat sources will result in blood pressure changes and a differential glycemic response

Time frame: 5 separate mornings, blood pressure measurements will be taken at baseline, 60, 120 and 180 minutes. Blood samples will be taken at baseline 15, 30, 45, 60, 90 and 120 minutes

Central Contacts

Thanh Ho, BSc

CONTACT

416-864-6060 hoho@smh.ca

Data from ClinicalTrials.gov

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