Effects of Navigated Repetitive Transcranial Magnetic Stimulation According to Post-stroke Aphasia Types

N/ACompletedNCT01877161

Seoul National University Bundang Hospital12 enrolled

Overview

Repetitive transcranial magnetic stimulation induced virtual lesions for aphasia.

To evaluate the effect of navigated repetitive transcranial magnetic stimulation in subjects with aphasia after stroke.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

To Healthy Volunteer Virtual Lesions for Aphasia

Interventions

Repetitive magnetic stimulation to superior temporal gyrusDEVICE

Repetitive magnetic stimulation to superior temporal gyrus

Repetitive magnetic stimulation to middle temporal gyrusDEVICE

Repetitive magnetic stimulation to middle temporal gyrus

Repetitive magnetic stimulation (Sham)DEVICE

Repetitive magnetic stimulation (Sham)

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * fluent in Korean * older than 18 years old Exclusion Criteria: * younger than 18 years old * psychotic or psychiatric problems * pregnant * contraindications to MRI/fMRI * uncooperative * metalic implants, pacemaker or cochlear implants * cannot perform outcome measure-related task * known seizure history

Locations (1)

Seoul National University Bundang Hospital

Seongnam-si, Bundang-gu, South Korea

Outcomes

Primary Outcomes

The Change of Reaction Time Between Before and After Stimulation in Each Session (MTG, STG, Sham)

Reaction time for lexical and repetition test were measured before and after the TMS stimulation at each sessions (at session 1, session 2, session 3 over MTG/STG/Sham; MTG: middle temporal gyrus, STG: superior temporal gyrus). Response times were measured via the response pad, and spoken responses were recorded via a SV-1 Voice Key apparatus. The "reaction time post TMS - reaction time pre TMS" were used for analysis.\* Arm/Group Title Arm/Group Description Maximum length (999) Repetitive magnetic stimulation (rTMS) were applied over STG

Time frame: change between before and after the TMS stimulation for each sessions (at session 1, session 2, session 3)

Data from ClinicalTrials.gov

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