The purpose of this study is to explore the impact of an intradialytic exercise program on functional capacity, aerobic capacity, strength, quality of life, depression, hospitalizations and intradialytic episodes of hypotension. The investigators would also like to look at the impact of exercise training over twelve weeks on hemoglobin levels as well as the clearance of potassium, phosphate and urea. Our hypothesis is that the above mentioned outcomes will positively improve over the twelve week intervention.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
50
12 weeks of intradialytic biking at Borg intensity 3 - 4 for 15 to 60 minutes on each dialysis run
Northwest Dialysis Centre
Calgary, Alberta, Canada
Functional Capacity
Functional capacity is measured by the DASI score which gives an estimated V02 peak in ml/min/kg. The difference between the mean score at baseline and 12 weeks will be determined.
Time frame: 12 weeks
Aerobic capacity
Aerobic capacity is measured as a function of the DASI score
Time frame: 12 weeks
Strength
Strength is determined as bilateral hand grip strength (measured in kg) as well as by the 30 second sit to stand test(the number of repetitions achieved in 30 seconds). These measures are obtained at baseline and again at 12 weeks.
Time frame: 12 weeks
Quality of life
The KDQOL- SF36 will be used to measure the quality of life at baseline and again at 12 weeks.
Time frame: 12 weeks
Hospitalizations
The number and rate of hospitalizations will be determined prior to exercise start and during the 12 week exercise program. Length of stay is also tracked.
Time frame: 12 weeks
Hypotension
Intradialytic hypotension, defined as a drop in systolic blood pressure (SBP) of 20 mmHg for patients with pre-dialysis blood pressure \> 100 mmHg or a drop in SBP of 10 mmHg for patients with pre-dialysis blood pressure \< = 90 mmHg. IDH with patient symptoms and nursing interventions will be obtained as well.
Time frame: 12 weeks
Hemoglobin levels
The baseline hemoglobin and hemoglobin at 12 weeks will be tracked.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: 12 weeks
Potassium levels
The baseline potassium and potassium at 12 weeks as well as the K gradient (pre -dialysis - dialysate K level)will be monitored.
Time frame: 12 weeks
Urea removal
The baseline and 12 week pre and post dialysis urea levels will be monitored.
Time frame: 12 weeks
Phosphate levels
The baseline and 12 week pre-dialysis phosphate levels will be tracked.
Time frame: 12 weeks
Bioimpedance derived volume and body mass determinations
In a small subset of patients (n=10) the bioimpedance derived fluid compartments (ECF, ICF, E:I ratio) and fat free body mass will be determined at both baseline and 12 weeks.
Time frame: 12 weeks