The primary aim of this study was to compare the absolute and relative effectiveness of asthma management in paediatric patients in the UK on inhaled corticosteroid (ICS) maintenance therapy as extra-fine HFA-BDP (Qvar®) pressurised metered dose inhaler (pMDI) compared with fluticasone propionate (FP) pMDI.
Comparison of asthma control with extrafine-particle hydrofluoroalkane-beclometasone (EF HFA-BDP) vs fluticasone propionate (FP) in paediatric patients (5-11year olds). Patients identified from the General Practice Research Database (GPRD) and the Optimum Patient Care Research Database (OPCRD). Two analyses were conducted: 1. Comparison of outcomes achieved by EF HFA-BDP and FP in 5-6year old patients with those achieved in 7-11yr old patients. 2. Comparison of outcomes achieved by EF HFA-BDP used with or without a spacer to those achieved by standard particle fluticasone propionate (FP) used with a spacer.
Study Type
OBSERVATIONAL
Enrollment
2,654
Proxy risk domain asthma control
Defined as the absence of the following during the one-year outcome period: 1. Asthma-related: * Hospital attendance or admission, OR * A\&E attendance, OR * Out of hours attendance, OR * Out-patient department attendance 2. GP consultations for lower respiratory tract infection 3. Prescriptions for acute courses of oral steroids .
Time frame: One year outcome period
Asthma exacerbation rate ratio
Where exacerbations are defined as an occurrence of: Defined as an occurrence of: 1. Asthma related: * Hospital admission, OR * A\&E attendance, OR 2. Use of acute oral steroids.
Time frame: One year outcome period
Overall asthma control
Risk domain asthma control as defined above, plus (a)Average prescribed daily dose of albuterol or terbutaline of ≤200mg
Time frame: One year outcome period
Hospitalisation rates
Asthma-related hospitalisations 1. Definite: Hospitalisations coded with an asthma read code 2. Definite and probable: Hospitalisations with an asthma read code and uncoded hospitalisations occurring within a 7-day window (either side of the hospitalisation date) of an asthma read code Respiratory hospitalisations 1. Definite: Hospitalisations coded with a lower respiratory code 2. Definite and probable: Hospitalisations with a lower respiratory read code and uncoded hospitalisations occurring within a 7-day window (either side of the hospitalisation date) of a lower respiratory read code
Time frame: One year outcome period
Treatment success
Asthma control and no change in therapy
Time frame: One year outcome period
Adherence to ICS therapy
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Categorised as: \<50%, 50-\<70%, 70-\<100%, ≥100%.
Time frame: One year outcome period
Use of short-acting beta2-agonist ("reliever") therapy
Time frame: One year outcome period