HSV Oral Reactivation in Children

Dartmouth-Hitchcock Medical Center30 enrolled

Overview

In the proposed study, the investigators will carry out novel research to evaluate both symptomatic and asymptomatic daily oral herpes simplex virus (HSV) shedding rates and copy number in children with and without HIV. Study Objectives: 1. To evaluate the frequency of oral HSV reactivation in HIV-infected and uninfected children Secondary Objectives: 2. To determine the acceptability of performing daily oral swabs in children age 3-12

Study Type

OBSERVATIONAL

Enrollment

Conditions

HSV-1 HIV

Interventions

Underlying medical illnessOTHER

Eligibility

Sex: ALLMin age: 3 YearsMax age: 12 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age \> 3 and ≤12 years old * parental/guardian consent and children's assent must be obtained and participants and parent/guardian must be able to comply with study procedures * For HIV-infected group: Positive HIV serology by either ELISA x 2, ELISA + WB or PCR testing Exclusion Criteria: * age \<3 and \> 12 years old * Acute illness which by opinion of the investigator makes enrollment in the trial unfeasible (including active tuberculosis, malaria or other opportunistic infection requiring treatment) * co-enrollment in other therapeutic/intervention trials (observational trial enrollment is permitted). * Stable co-administration of other medications is permitted (e.g. bactrim) * For HIV-infected children; receiving or eligible for antiretroviral (ART) therapy by local standards

Locations (1)

MUHAS

Dar es Salaam, Tanzania

Outcomes

Primary Outcomes

HSV detection rate

Time frame: 14 days

Secondary Outcomes

HSV copy number

Time frame: 14 days

Data from ClinicalTrials.gov

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