The Effects of Altering Physical Activity on Cardiometabolic Health

University of Kansas Medical Center13 enrolled

Overview

The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular health. Specifically, the investigators wish to examine in healthy, lean physically active individuals (obtaining greater than 10,000 steps/day) if decreasing physical activity (obtaining less than 5,000 steps/day) will alter blood flow following a meal a marker of vascular health. Furthermore, the investigators wish to examine if a one day return to physical activity (obtaining \>10,000 steps/day) can restore the detrimental effects on blood flow following a meal.

Herein, we tested the hypothesis that an acute reduction in daily activity (from \>10,000 to \<5,000 steps/day) for 5 days in healthy individuals reduced meal-stimulated blood flow and if a 1 day return to activity improved this outcomes.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Insulin Resistance

Interventions

Eligibility

Sex: ALLMin age: 19 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI: less than 30 kg/m2 * Physically active: exercise greater than 60mins per week Exclusion Criteria: * smoking * type 2 diabetes * Underlying conditions that limit ability to exercise safely * Recent weight gain or loss(\> 5% of body weight in 3 months) * Recent (\< 3 mo) changes in medication use or dose * Pregnancy

Outcomes

Primary Outcomes

Effects of Physical Inactivity on Post Prandial Blood Flow

There was a pre-measurement period of 3 days, then 5 days of inactivity, followed by 1.5-2 days of return to activity. A 10 day time frame overall. Blood flow measured by Doppler ultrasound during an oral glucose tolerance test before and after 5 days of inactivity.

Time frame: 10 days