Effect of Ventilation Mode on Lung Deposition of a Radiolabeled Aerosol During Mechanical Ventilation: Barometric Versus Volumetric

Cliniques universitaires Saint-Luc- Université Catholique de Louvain19 enrolled

Overview

Controlling the respiratory pattern of mechanically ventilated patients in volume control mode is recommended during nebulization. No studies looked into conditions of nebulization during assisted mechanical ventilation to define the optimal nebulization technique and its effect on pulmonary deposition. The aim of this study is to analyse the effect of ventilation mode (barometric versus volumetric) on deposition by planar scintigraphy during mechanical ventilation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Post-operative Neurosurgery

Interventions

technetium-99m - Diethylenetriaminepentaacetic acid

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Invasive mechanical ventilation * Healthy lungs Exclusion Criteria: * Change of ventilation mode during nebulization

Locations (1)

Cliniques Universitaires Saint-Luc

Brussels, Belgium

Outcomes

Primary Outcomes

Pulmonary deposition

Time frame: Immediately after nebulization by imaging assessment, an expected average of 30 minutes

Secondary Outcomes

Penetration index

Time frame: Immediately after nebulization by imaging assessment, an expected average of 30 minutes

Mechanical ventilation settings

Time frame: During nebulisation time, an expected average of 15 minutes

Lung function

Time frame: Preoperative assessment, the day before inclusion

Data from ClinicalTrials.gov

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